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Minor in Biomanufacturing

The purpose of an undergraduate minor is to help NC State students acquire knowledge that supports their major and adds breadth to their education. Students from a wide variety of majors take BTEC courses in order to gain hands-on experience in a simulated-cGMP* environment to prepare them for rapidly growing fields in biomanufacturing. *current Good Manufacturing Practice

Biomanufacturing refers to the use of cells or other living microorganisms to produce commercially viable products. Vaccines, monoclonal antibodies, and proteins for medicinal use are all produced by biomanufacturing. Other examples include amino acids, industrial enzymes, biofuels, and biochemicals for consumer and industrial applications. Biomanufacturing is an interdisciplinary field incorporating aspects of chemical engineering, biochemistry, and microbiology.

Requirements

The following prerequisites must be completed with a grade of C- or better to enter the minor.

Course # Course Title Credit Hours
BIO 183 Introductory Biology: Cellular and Molecular Biology 4
CH 101 Chemistry - A Molecular Science 3

A minimum of 15 credit hours is required to earn the minor. Review the five categories below to see how hours are allocated.

  1. Introductory Seminar Pertaining to Biomanufacturing (1 credit)
    Course # Course Title Credit Hours
    BEC 220 Introduction to Drug Development and Careers in Biomanufacturing 1
  2. Basic Microbiology Laboratory Skills (1 credit minimum)
    Any of the following courses fulfill this requirement. (Student transcripts will note all credit hours earned.)
    Course # Course Title Credit Hours
    BEC 363 Foundations of Recombinant Microorganisms for Biomanufacturing 2
    BIT 410 Manipulation of Recombinant DNA 4
    MB 352 General Microbiology Laboratory 1
    MB 354 Inquiry-Guided Microbiology Lab 1
  3. Base Biomanufacturing Sequence (4 credits)
    Both of the courses listed below are required.
    Course # Course Title Credit Hours
    BEC 330 Principles and Applications of Bioseparations 2
    BEC/CHE 463 Fermentation of Recombinant Microorganisms 2
  4. Biomanufacturing Specialization (4 credits)
    Students must complete a two-course specialization sequence focused on either upstream or downstream operations. Course selections are listed below.

    Upstream operations
    Course # Course Title Credit Hours
    BEC 426 Upstream Biomanufacturing Laboratory 2
    BEC 480 cGMP Fermentation Operations 2
    Downstream operations
    Course # Course Title Credit Hours
    BEC 436 Introduction to Downstream Process Development 2
    BEC 485 cGMP Downstream Operations 2
  5. Electives (5 credits minimum)
    Students must complete at least 5 credits of courses from the list below. Courses used to fulfill the biomanufacturing specialization (see section above) may not be counted toward this requirement.
    Course # Course Title Credit Hours
    BAE/BBS 425 Industrial Microbiology and Bioprocessing 3
    BCH 351
    or BCH 451
    General Biochemistry
    Principles of Biochemistry
    4
    BEC 426 Upstream Biomanufacturing Laboratory 2
    BEC 436 Introduction to Downstream Process Development 2
    BEC 440 Expression Systems in Biomanufacturing 3
    BEC 442 Insect Cells Protein Expression 2
    BEC 462 Fundamentals of Bio-Nanotechnology 3
    BEC 475 Global Regulatory Affairs for Medical Products 3
    BEC 480 cGMP Fermentation Operations 2
    BEC/BME 483 Tissue Engineering Technologies 2
    BEC 485 cGMP Downstream Operations 2
    BEC 488 Animal Cell Culture Engineering 2
    BEC 497 Biomanufacturing Research Projects 2 maximum
    BIT 410 Manipulation of Recombinant DNA 4
    BIT 466 Animal Cell Culture Techniques 2
    GN 311 Principles of Genetics (previously GN 411) 4
    MB 455 Microbial Biotechnology 3

Minors are awarded at graduation; they may not be awarded after a student has received the associated degree at NC State except in those cases in which a student continues enrollment for a second or third undergraduate degree.

For more information

For additional information about the BTEC undergraduate minor, contact Winnell Newman, manager of student programs, at 919-515-0213 or winnell_newman@ncsu.edu.