Facilities and Equipment

BTEC's large-scale fermentation lab

Training facilities

To meet industry demands for students skilled in the operation of equipment and processes that are unique to biomanufacturing, BTEC is dedicated to providing hands-on training using state-of-the-art facilities and equipment. The 77,700 gross-square-foot main facility features high-tech classrooms and laboratories with bench-scale and pilot-scale bioprocessing equipment. In addition, the BTEC Annex has approximately 5,000 gross square feet for viral processing, cell culture, and purification. The largest laboratory area is a simulated-cGMP (current Good Manufacturing Practice) production facility.

BTEC's training facilities feature:

  • 7,200 gsf high-tech classrooms
  • 43,700+ gsf lab training space
  • Stainless steel bioreactors at 30 L and 300 L scales
  • Disposable bioreactors
  • Automation with next-generation distributed control architecture
  • Analytical lab
  • Downstream separation and purification processes
  • Aseptic processing operations
  • Numerous bench-scale labs to enable learning in next-generation biotechnology and biomanufacturing technologies such as animal cell and tissue culture, virus processing, protein and metabolic engineering, miniaturization, high throughput technologies, and bioanalytical methodologies

Floor plans

Shaded areas on the first-floor and second-floor plans indicate spaces that can be seen on the BTEC virtual tour.

Bioprocess equipment and analytical instrumentation

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Upstream Processing

Bench-scale bioreactors

Ambr 250 Modular System
Ambr 250 Modular System
  • 2L Bioreactors (14)
  • Ambr 250 Modular System (8 stations)
  • Biosafety cabinets (numerous)
  • Incubator/shakers (numerous)
  • Microscopes (numerous)

Stainless steel bioreactors

Sartorium Stedim 30L bioreactor
Sartorium Stedim 30L bioreactor
  • 30L Bioreactors (5)
  • 30L and 300L Bioreactors with DeltaV control
  • 30L and 300L Bioreactors with Sartorius controllers

Disposable bioreactors

Sartorius Biostat Cultibag rocker bioreactor
Sartorius Biostat Cultibag rocker bioreactor
  • 20L Rocker bioreactors (2), 50L platform available
  • 50L Bioreactor – Finesse controller
  • 50L Bioreactor – Xcellerex
  • 250L Bioreactor
  • Perfusion system – ATF 2 device ( 2 controllers)

Downstream Processing

Small-scale cell separation

  • Benchtop centrifuges (numerous)
  • Bottle centrifuge

Large-/intermediate-scale cell separation

Alfa Laval LAPX404SGP-31 centrifuge
Alfa Laval LAPX404SGP-31 centrifuge
  • Bench-top, Westfalia disk-stack centrifuges (2)
  • Harvest vessels (numerous)
  • Large-scale Alfa Laval disk-stack centrifuge

Filtration for solid-liquid separation

  • Pilot-scale depth filtration holders


Beckman Coulter Optima XPN-80 ultracentrifuge
Beckman Coulter Optima XPN-80 ultracentrifuge
  • Beckman Coulter Optima XPN-80 ultracentrifuge

Cell lysis

  • Bench-top high pressure homogenizers (2)
  • Large-scale high pressure homogenizer

Bench-top chromatography

AKTA Avant chromatography unit
AKTA Avant chromatography unit
TECAN Freedom EVO delivery system
TECAN Freedom EVO delivery system
  • Bench-top chromatography units (3) – AKTA Avant
  • Bench-top chromatography units (4) – AKTA Pure
  • BioSMB PD multi column chromatography
  • TECAN Freedom EVO delivery system

Large-scale chromatography

Mobius XM02 single-use chromatography skid
Mobius XM02 single-use chromatography skid
  • Chromatography columns: AxiChrom 300/300, BPG 140/500, BPG 300/500, INdEX 200/500
  • Chromatography skids – AKTAprocess (2)
  • Single-use chromatography skid – Mobius XM02


  • Bench-top TFF systems (9)
  • Large-scale TFF system

Final Fill and Finish

Fill and storage

  • Buffer storage area
  • Bulk filling machines (2)
  • Cold room
  • Modular fill room


Buchi B290 spray dryer
Buchi B290 spray dryer
  • Mini spray dryer
  • Moisture analyzer

Supporting Operations

Solution preparation

  • 100-200L Disposable mixers
  • 250L Disposable mixer
  • 600L Buffer prep tank
  • Buffer totes, 200L and 500L (numerous)

Cleaning, sanitization, and sterilization

  • Autoclaves
  • CIP skid
  • Parts washers

Process Utilities

  • Air compressors (2)
  • Clean gas distribution system
  • Clean steam generator
  • High purity water system
  • Waste treatment system

Product Characterization

Analytical instrumentation

Vironova miniTEM transmission electron microscope
Vironova miniTEM transmission electron microscope
Roche BioHT analyzer
Roche BioHT analyzer
  • Advanced Instruments osmometer
  • Beckman cell viability analyzers (ViCELL Blu and XR)
  • Beckman Metaflex metabolite and substrate analyzer
  • Benchtop FTIR
  • Biotage Syro I Peptide Synthesizer
  • BioTek Cytation 5 Cell Imaging Multi-Mode Reader
  • Capillary electrophoresis
  • CD spectrometer
  • ClonePix 2 Mammalian Colony Picker
  • DNA sequencer
  • Droplet Digital PCR system
  • Endotoxin analyzer – Endosafe nexgen-PTS
  • Gas chromatography/mass spec
  • HPLC (4)
  • Liquid chromatography/mass spec (multiple)
  • MALDI-TOF mass spec
  • MALLS analyzer
  • Modular rheometer
  • Multimode plate reader (2)
  •  PCR
  • qPCR system
  • Roche BioHT metabolite and substrate analyzer
  • Scanning electron microscope
  • Spectrophotometers (numerous)
  • TOC analyzer
  • Unchained Labs Uncle
  • UPLC (2)
  • Vironova miniTEM transmission electron microscope

Process Monitoring

In-line/on-line process analyzers

  • FT-NIR with PAT Manager
  • Process mass spec
  • Raman – RxN2 Analyzer

Off-line process analyzers

  • Biochemical analyzers (numerous)
  • Cell mass/number analyzers (numerous)