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BioPhorum Operations Group to present at Bioprocess International West Conference

Published Feb. 15, 2017

At the upcoming BioProcess International West Conference in San Francisco, Dr. Scott Probst will give a presentation about the work that the BioPhorum Operations Group (BPOG) and BTEC have conducted. Dr. Probst is Head of Process Technology Development, Biologics, in the Engineering and Technology department of Bayer US LLC. He will speak on “Data-driven and risk-based approaches for area classification selection for biopharmaceutical processes”. For over two years, BTEC has provided BPOG with facilities and expertise to culture organisms, conduct bioburden testing, and execute experiments utilizing a test skid provided by Bayer. Bayer is a member of BPOG, which provides an environment for senior leaders of the biopharma industry to come together and openly share and discuss the emerging trends and challenges facing their industry.

Dr. Probst’s presentation, part of the Single Use/Flexible Facilities track, is scheduled for Thursday, March 2, 2017, at 10:15 a.m. He will describe the work that BPOG and BTEC have conducted to understand the effect of different liquid cleaning protocols in the selection and operation of functionally-closed connections in controlled, non-classified environments. The studies suggest that functionally-closed connections in CNC areas are most likely cleaner than open connections in Grade C environments and therefore may be considered for low-bioburden manufacturing processes in CNC environments. Dr. Probst will also describe the effect of gaseous ozone disinfection as an alternative sanitization procedure, a study conducted in a three-way partnership between BTEC, Bayer and Bürkert Fluid Control Systems. This part of the study suggests that ozone treatment provides much higher log reduction factors than liquid cleaning alone.