Content

Facilities and Equipment

Training facilities

To meet industry demands for students skilled in the operation of equipment and processes that are unique to biomanufacturing, BTEC is dedicated to providing hands-on training using state-of-the-art facilities and equipment. The 77,700 gross-square-foot main facility features high-tech classrooms and laboratories with bench-scale and pilot-scale bioprocessing equipment. In addition, the BTEC Annex has approximately 5,000 gross square feet for viral processing, cell culture, and purification. The largest laboratory area is a simulated-cGMP (current Good Manufacturing Practice) production facility.

BTEC's training facilities feature:

• 7,200 gsf high-tech classrooms
• 43,700+ gsf lab training space
• Stainless steel bioreactors at 30 L and 300 L scales
• Disposable bioreactors
• Automation with next-generation distributed control architecture
• Analytical lab
• Downstream separation and purification processes
• Aseptic processing operations
• Numerous bench-scale labs to enable learning in next-generation biotechnology and biomanufacturing technologies such as animal cell and tissue culture, virus processing, protein and metabolic engineering, miniaturization, high throughput technologies, and bioanalytical methodologies

Floor plans

Shaded areas on the first-floor and second-floor plans indicate spaces that can be seen on the BTEC virtual tour.

• Basement
• First floor
• Second floor

Bioprocess equipment and analytical instrumentation

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Upstream Processing

• 2L Bioreactors (14)
• Ambr 250 Modular System (8 stations)
• Biosafety cabinets (numerous)
• Incubator/shakers (numerous)
• Microscopes (numerous)

• 30L Bioreactors (5)
• 30L and 300L Bioreactors with DeltaV control
• 30L and 300L Bioreactors with Sartorius controllers

• 20L Rocker bioreactors (2), 50L platform available
• 50L Bioreactor – Finesse controller
• 50L Bioreactor – Xcellerex
• 250L Bioreactor
• Perfusion system – ATF 2 device ( 2 controllers)

Downstream Processing

• Bench-top, Westfalia disk-stack centrifuges (2)
• Harvest vessels (numerous)
• Large-scale Alfa Laval disk-stack centrifuge

• Beckman Coulter Optima XPN-80 ultracentrifuge

• Bench-top chromatography units (3) – AKTA Avant
• Bench-top chromatography units (4) – AKTA Pure
• BioSMB PD multi column chromatography
• TECAN Freedom EVO delivery system

• Chromatography columns: AxiChrom 300/300, BPG 140/500, BPG 300/500, INdEX 200/500
• Chromatography skids – AKTAprocess (2)
• Single-use chromatography skid – Mobius XM02

Final Fill and Finish

• Mini spray dryer
• Moisture analyzer

Supporting Operations

Product Characterization

• Advanced Instruments osmometer
• Beckman cell viability analyzers (ViCELL Blu and XR)
• Beckman Metaflex metabolite and substrate analyzer
• Benchtop FTIR
• Biotage Syro I Peptide Synthesizer
• BioTek Cytation 5 Cell Imaging Multi-Mode Reader
• Capillary electrophoresis
• CD spectrometer
• ClonePix 2 Mammalian Colony Picker
• DNA sequencer
• Droplet Digital PCR system
• Endotoxin analyzer – Endosafe nexgen-PTS
• Gas chromatography/mass spec
• HPLC (4)
• Liquid chromatography/mass spec (multiple)
• MALDI-TOF mass spec
• MALLS analyzer
• Modular rheometer
• Multimode plate reader (2)
•  PCR
• qPCR system
• Roche BioHT metabolite and substrate analyzer
• Scanning electron microscope
• Spectrophotometers (numerous)
• TOC analyzer
• Unchained Labs Uncle
• UPLC (2)
• Vironova miniTEM transmission electron microscope

Process Monitoring