Content

Combinatorial and Evolutionary Engineering of Probiotic Yeast for in situ Biomanufacturing

Part of the BTEC Spring 2024 Seminar Series

Friday, Mar. 22, 2024
10:00–11:30 a.m. EST
BTEC room 135
Zoom: go.ncsu.edu/btec_seminar

The large intestine is the site of many human diseases yet is difficult to access with orally- or intravenously-delivered drugs. At the same time, the gut provides a habitat for a numerous and diverse population of microbes that perform important, health-relevant chemistries. In this talk, Nathan Crook, Ph.D., will discuss his lab’s recent progress in tuning four key parameters of Saccharomyces boulardii (Sb) efficacy as a drug delivery vehicle. Taken together, this work establishes Sb as a genetically tractable commensal fungus and demonstrates the tunable delivery of small-molecule and protein therapeutics during colonization.

Presented by:
Accelerated Innovation in Manufacturing Biologics (AIM-BIO)

Speaker

Nathan Crook, Ph.D.
Assistant Professor, Chemical and Biomolecular Engineering
NC State University