Content

Translating PROTAC Technology to Tune the UPS Across Plants, Fungi and Insects

Part of the BTEC Fall 2023 Seminar Series

Friday, Sept. 15, 2023
10:40–11:30 a.m. EST
BTEC room 135

Through Attune™, Oerth Bio's proprietary R&D platform, they are harnessing the natural ubiquitin proteasome system (UPS) to modulate protein levels to illicit a phenotypic effect. Attune is targeting, modulating, and tuning the UPS system across plants, insects, and fungi for specific outcomes to help crops thrive in the face of disease, pest, and climate pressures. Attune integrates three key pillars to develop precise, tunable, agricultural solutions: Ligase selection & Ligand Identification, Rapid PROTAC Design, and Agricultural validation. Their robust library of E3 ligases, linkers, and ligands enables them to conduct virtual and high-throughput screening of target proteins from specific plants and pests.

Speaker

Kelly D.D. Broccio, Ph.D.
Senior Director of Targeted Protein Degradation
Oerth Bio