Content
Breadcrumbs
Establishing Saccharomyces boulardii as an in-gut biomanufacturing platform
Part of the BTEC Spring 2022 Seminar Series
Friday, Feb. 25, 2022
10:40–11:30 a.m.
Speaker
Nathan Crook, Ph.D.
Assistant Professor
Department of Chemical and Biomolecular Engineering
NC State University
Saccharomyces boulardii is a widely used yeast probiotic, demonstrating effectiveness against various gastrointestinal disorders. S. boulardii is a promising chassis for development of personalized engineered probiotic medicines. In this talk, Nathan Crook, Ph.D. will discuss the Department of Chemical and Biomolecular Engineering lab’s recent progress in optimizing both small molecule and peptide biosynthesis in this strain, as well as their efforts to enhance S. boulardii’s in vivo residence time. Last, Dr. Crook will discuss some new work from CBE's lab focusing on the development of gut- and small-molecule inducible promoters for this organism. Taken together, this work establishes S. boulardii as a genetically tractable commensal fungus and demonstrates the delivery of therapeutics during colonization.