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Bioprocess and Analytical Services

Bioprocess equipment and analytical instrumentation bench-scale bioreactors stainless steel bioreactors 20 L and 50 L disposable bioreactors 50 L and 250 L disposable bioreactors in-line/on-line process analyzers at-line process analyzers at-line process biochemical analyzers small-scale cell separation cell separation cell lysis bench-top chromatography large-scale chromatography ultrafiltration/diafiltration solution preparation fill and storage cleaning and sterilization analytical PLCs analytical mass spec analytical electrophoresis, analyzer analytical PCR, DNA sequencer analytical plate reader, analyzer, spectrometer process utilities

Solutions and services for industry, government and academia

BTEC offers access to its facilities, equipment, and the expertise of its faculty and staff to solve the toughest scientific problems. To answer your needs for process execution, process development, analytical testing and development, and technology development, BTEC can...

  • Supply material for research and preclinical studies
  • Generate process data during scale-up
  • Collaborate on process development projects
  • Enable technology development in a risk-free environment (for example, testing prototypes of new products)
  • Provide access to industry-standard equipment at a range of scales
  • Furnish routine analytical testing services and
  • Consult regarding analytical development needs

The BTEC facility contains approximately 63,000 square feet of state-of-the-art laboratories from bench to simulated cGMP pilot scale. Upstream and downstream equipment includes:

  • Steam sterilizable bioreactors ranging from 2-L to 300-L scale, for fermentation and cell culture projects
  • Disposable bioreactor systems for mammalian cell culture applications with volumes from 10 L to 250 L
  • Both bench and pilot-scale high-pressure homogenizers, centrifuges, chromatography systems and tangential flow filtration systems for protein recovery and purification

In BTEC's analytical lab, capabilities range from HPLC, UPLC, ELISA, gel electrophoresis, capillary electrophoresis, MALDI-TOF and quantitative PCR. BTEC also offers assay development and validation services. Typical tests performed include:

  • Protein quantity and purity
  • Protein fingerprinting
  • Spectral characterization
  • MW determinations
  • Host cell DNA contamination
  • Microbial identification
  • Amino acid analysis
  • TOC analysis
  • Endotoxin
  • Bioburden
  • Total protein

BTEC is also equipped with a host of support systems required for biopharmaceutical production, including buffer prep capabilities, process utilities including clean steam and high purity water, glasswashers and autoclaves.

The expertise of BTEC's talented scientists, engineers and operations staff is just as impressive as our facilities and equipment. BTEC personnel involved in bioprocess and analytical projects have wide-ranging experience—from cGMP fermentation, cell culture and downstream operations to upstream and downstream process development and analytical development. Our scientists and staff have years of industrial experience with leading firms such as Eli Lilly and Co., Bristol-Myers Squibb, Wyeth, Diosynth Biotechnology, Johnson & Johnson, Nabi Biopharmaceuticals, Biogen Idec and Talecris Biotherapeutics.

To discuss how BTEC can provide services or solutions for your firm, contact Jennifer Pancorbo, jennifer_pancorbo@ncsu.edu, or Nat Hentz, nat_hentz@ncsu.edu, today!