Latest Trends in Downstream Biopharmaceutical Processing

online course
downstream course

This course can count toward your Professional Certificate in Biomanufacturing Science.

Why should you take this course?

Downstream processing of biological products currently relies on a number of traditional unit operations—centrifugation, depth filtration, chromatography, and ultrafiltration. While these unit operations successfully harvest and purify biotherapeutic materials, they are also time consuming and relatively expensive. Attending this course will provide insight into alternatives and improvements to these well-established unit operations related to productivity, cost, and overall process flexibility.

Participate and you will learn

  • Theoretical and operational principles that underlie the unit operations presented, which include centrifugation, precipitation, crystallization, aqueous two-phase extraction (ATPE), single-pass ultrafiltration, and chromatography
  • Where in the downstream process each technology can be used
  • The advantages and limitations of each technology
  • To recognize process scenarios that favor these up-and-coming technologies and those that do not

Who should participate

Scientists with some experience in downstream bioprocessing who are interested in the latest technologies and methods available. These individuals may include the following:

  • Process development scientists and process engineers designing downstream processes
  • Manufacturing managers and directors involved in downstream manufacturing
  • Process validation scientists
  • Vendors of downstream processing technologies interested in where the technology may be heading
  • Faculty and graduate students working in the area of downstream biopharmaceutical processing

Course format

This course is self-paced and delivered totally online. This on-demand format enables participants to access—for 90 days—a series of recorded lectures with interactive components that have been created for independent, self-paced learning. The course is always available except for brief maintenance periods, and because no scheduled meetings or other real-time events are included, you can access materials whenever it's convenient. The course is presented through NC State's learning management system, Moodle; upon registration, participants are provided with instructions for accessing the course website. Note that although lecture recordings are not downloadable, PDF versions of slides are available to participants.


Materials are divided into three modules, listed below, and each module contains several lectures.

  1. Overview of Biopharmaceutical Products and Processes
  2. Latest Trends in Non-Chromatographic Approaches
  3. Latest Trends in Chromatographic Approaches


Register and you will receive

  • Access to approximately 14 hours of online materials
  • Course certificate upon completing all course assessments

Register now




Payment by credit card must be made at the time of registration. Prior to registration, please direct any questions to

Pre-course communication

Upon successful registration for a course, you will receive an automatically generated email with information about how to access the online materials. If you do not receive this email within one business day of registering, please email Scott Latus at

Short course cancellations


Enrollment may be canceled within 10 business days (minimum two weeks) of the registration, subject to the conditions noted below. A 50% cancellation fee is charged for each registration canceled. Refund of the remainder of the registration price is subject to the following conditions:

  • The course material must not have been accessed by the registrant.
  • The registrant must request the cancellation within 10 business days of the registration.

To cancel a registration and be eligible for a refund of course fees, you must notify BTEC by e-mail to


Cancellation by BTEC does not apply to this course.