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Complimentary luncheon seminar: Viral vector purification through monolithic products

Aleš Štrancar, Ph.D., chief executive officer of BIA Separations, will present a free seminar on the use of monolithic products for viral vectors purification on Wednesday, June 19, at BTEC.

One of the key challenges in manufacturing viral vectors is managing the interface between upstream and downstream processing. Experimental observations indicate that, in addition to losses due to shear, processing methods such as precipitation, freeze/thaw and tangential flow filtration (TFF) promote formation of stable associations between virus, DNA and proteins. These complexes lower virus recovery and process capacity, depress robustness, and inflate contamination at each processing step. Accordingly, they have strong potential to influence long-term clinical safety, especially with respect to residual DNA. Dr. Štrancar will discuss how  monolithic products are engineered specifically to address these issues, and attendees will gain an in-depth understanding of how and why monoliths are the best tool for purification of viral vectors.

As part of the program, lunch will be provided by BIA Separations. For more information and to register, email Sara Primec at sara.primec@biaseparations.com. While attendance is free, space is limited, so please register early. The registration deadline is June 7, 2019.

BIA Separations is the leading developer and manufacturer of Convective Interaction Media (CIM) monolithic columns for fast purification of biomolecules. Its products range from small analytical columns to large industrial prep-scale columns (including cGMP and disposable units) as well as method development services. For more information, visit www.biaseparations.com.