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From Capture to Polish: Using Mixed-Mode and High-Resolution Chromatography Resins for Virus Purification and mAb Aggregate Removal

Join Bio-Rad Laboratories at BTEC to learn about unique resin selectivities for process purification and best practices to purify challenging biomolecules. The key takeaways of this session are:

  • How different mixed-mode selectivities affect virus purification
  • The ease of aggregate clearance using mixed-mode resins
  • Selecting the best resin to maximize impurity removal

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Agenda

09:00 – 09:30 Registration
09:30 – 09:40 Welcome
09:40 – 10:20 Cation exchange‑calcium affinity mixed‑mode media: How it works and how to screen it. Case study—mammalian virus purification
10:20 – 11:00 Hydrophobic cation exchange media: How it works and how to screen it. Case study—adenovirus purification
11:00 – 11:20 Aggregate Clearance with mixed mode resins
11:20 – 11:40 High‑resolution cation exchange resin for product‑related impurity removal: dimers, aggregates, and charge variants
11:40 – 12:00 Optimizing your purification system for screening resins
12:00 – 13:00 Lunch and open discussion

Following the last presentation, lunch will be served and attendees will have the opportunity to discuss the complexities of process development and how to streamline the purification process.