Content

Hands-On Viral Vaccine Manufacture

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Delivery methods

Course content

Why should you attend?

This five-day course provides those attending with a broad understanding of viral vaccine production. The course begins with an overview of vaccine fundamentals, including vaccine types, basic vaccine immunology, and virus types. Attention then shifts to those steps necessary to produce, recover and purify virus, using influenza A as a model for viral vaccines. Through a combination of lecture and hands-on laboratory activities, participants learn the fundamentals of egg-based and cell-based virus production and virus recovery and purification methods including ultracentrifugation, chromatography, and ultrafiltration. Basic analytical techniques for quantifying and characterizing virus are also examined. At the end of the course, attendees will have a thorough understanding of the "how and why" behind vaccine manufacture and consequently be better equipped to manufacture viral vaccines and troubleshoot vaccine processes.

Attend and you will learn

  • Vaccine classification and basic vaccine immunology
  • The principles—both fundamental and operational—that underlie key operations used in viral vaccine production including egg-based and cell culture-based virus production, "low-speed" centrifugation, ultracentrifugation, chromatography, and ultrafiltration
  • The critical process parameters CPPs) for each unit operation, how these parameters are monitored, and the effect that a change in CPP value will have on process performance
  • How vaccine products are characterized with respect to their safety, efficacy, and purity by means of quantitative assays

Who should attend

Anyone interested in obtaining a basic knowledge of the operations involved in production of viral vaccines and applying that knowledge in industry-like labs, such as the following:

  • Scientists and engineers who are new to viral vaccine production
  • Biomanufacturing supervisors and managers interested in learning about the parts of the vaccine process that they do not manage
  • Other personnel—including quality assurance, quality control, and validation professionals—who support vaccine manufacture but may not be directly involved with execution of the processes they support
  • Vendors who supply the vaccine industry with equipment and components

Attend and you will receive

  • 37.5 hours of instruction (3.7 Continuing Education Units)
  • Notebook containing all course lecture and lab materials
  • Morning coffee and tea
  • Lunch
  • Afternoon beverage break
  • Certificate of completion

Instructors

This course is facilitated by a team of BTEC and NC State faculty, including Driss Elhanafi, Ph.D., Gary Gilleskie, Ph.D., Matt Koci, Ph.D., and Jennifer Pancorbo, Ph.D.

Important Information for In-person Course Participants

Please read about BTEC’s policies on payment, cancellation, pre-course communication and other important information for in-person courses offered on site at BTEC.