Automation, Process Control, and Real-time Monitoring of Yeast Culture


Register for this course by selecting the above date.

Delivery methods

Course content

Why should you attend?

In this four-day, hands-on course, you will gain familiarity with and applied insight into the functionality of control equipment and instrumentation, and how process data from a model yeast fermentation is used to ensure a quality product. Participants will work with traditional sensors, a PAT soft sensor, and multivariate data analysis (MVDA) to monitor, model, and control the process.

This course will give professionals with experience in fermentation an in-depth introduction to process instrumentation and integrating operation with a process control system. Professionals will learn how process information is communicated and used for different engineering controls, including PID control, split-range control, and cascade control with the DeltaV distributed control system. A Raman spectral sensor and PLS model will also be deployed for process monitoring and control to familiarize participants with implementing Process Analytical Technology (PAT) in an upstream process. Participants will gain hands-on experience in using data analytics software to build a soft sensor model for metabolite monitoring and will use historical process data to build a real-time predictive model to monitor batch quality in real-time.

Attend and you will learn

  • To design and set up basic process monitoring, feedback, and control loop systems
  • To utilize a PAT sensor and a PLS model for process monitoring and feedback control
  • To use commercial MVDA software to model and monitor a yeast fermentation process

Who should attend

This course is intended for scientists and engineers familiar with biomanufacturing processes, and with some experience in fermentation, who are interested in gaining insight into how the control equipment functions and how process data is used to ensure a quality product. This course is appropriate for upstream process engineers interested in learning more about automation/process control and validation specialists working on highly automated processes who are interested in learning more about using analytics and predictive modeling to monitor and improve quality. Participants do not need advanced knowledge of process automation or the use of analytics to build predictive models.

Attend and you will receive

  • 30 hours of instruction
  • Notebook containing all course lecture and lab materials
  • Morning coffee
  • Lunch
  • Afternoon beverage break
  • Certificate of attendance





All courses are offered on site at BTEC, other than online courses. The Golden LEAF BTEC building is located at 850 Oval Drive on NC State University's Centennial Campus.

If a course is full: Waitlist policy

If a course you want to take is already full, you are welcome to email and ask to be placed on a waitlist for that course. The waitlist is used to fill any seats that become available when individuals registered for the course are unable to attend. If one or more seats become available, individuals on the waitlist are contacted in the order in which they were added to the list.

In addition to ensuring popular courses remain full, waitlists provide a means of tracking interest and determining if additional sessions are necessary. BTEC makes every effort to schedule additional course offerings if sufficient people are wait-listed. If a new offering is scheduled, those on the waitlist are notified before registration opens to the public.

Placement on a waitlist does not commit individuals to attending a course. It simply ensures that they are given first opportunity to enroll if a seat becomes available in a full course and that they are among the first to know if an additional course offering is scheduled during the current year.

BTEC is unable to provide information about the number of those wait-listed for any given course or an individual’s place on such a list.


BTEC strongly prefers payment by credit card at the time of registration. BTEC accepts payment from all major credit cards including American Express, Visa, and MasterCard. If you are not paying by credit card at the time of registration, please email to make arrangements immediately after registering and note the following:

  • If you wish to pay by PO or company check, please note that payment is due within 10 days of registration. If paying by PO, please reference PO number in your email, but note that a PO number will not hold a seat.
  • If no payment has been received within 10 business days of registration, BTEC reserves the right to cancel registration based on enrollment demand.
  • BTEC will add a 2% processing fee to the total cost of the course for all PO or company check payments.

Any additional questions prior to registration should be directed to

Discounts available

A 20% discount is available to:

  • Employees of BMF companies
  • Groups of five or more from one company registering for the same offering of this course
  • Individuals registering for more than one course at a time
  • Faculty/staff working in academic environments

A 40% discount is available for NIIMBL members for the following courses:

  • Hands-On cGMP Biomanufacturing of Vectors for Gene Therapy
  • Hands-on Essentials of Automation for Biomanufacturing

Check out BTEC’s professional development certificate program for an additional way to save money on short course costs.

Cancellation policies

Cancellation by registrant

To cancel a registration and be eligible for a refund of course fees, you must notify BTEC by e-mail to or fax to 919-513-1697. Fees are refunded according to the following schedule:

  • 100% refund – If notification is received at least 15 business days in advance of course start date
  • 75% refund – If notification is received 10–14 business days in advance of course start date
  • 50% refund – If notification is received 6–9 business days in advance of course start date
  • No refund will be issued if notice is received 5 or fewer business days in advance of course start

Substitutions may be made up to two business days prior to the course start date. Notify the BTEC office by fax at 919-513-1697 or by e-mail to Please include the name and email contact for the replacement. Please note that BTEC is unable to honor substitutions for individuals taking discounted courses as part of the professional development certificate program.

Cancellation by BTEC

BTEC retains the right to cancel a professional development short course no less than 10 business days in advance of the scheduled course start date. Registrants will be notified by BTEC if a course is cancelled and will receive a full refund of registration fees paid. BTEC is not responsible for airfare penalties or other costs incurred due to cancellation.

Pre-course communication

Upon successful registration for a course, you will receive an automatically-generated email as well as another email from Melody Woodyard confirming your registration. If you do not receive these emails within two business days of registering for a course, please email to confirm your registration.

Once registered, confirmed course participants will receive an email approximately three weeks before the scheduled course with detailed information regarding travel to BTEC, parking information, and a short pre-course questionnaire.