Protein Precipitation and Crystallization
Register for this course by selecting the date above.
|10% Discussion/group activity|
|55% Hands-on lab experience|
|40% Fundamentals and concepts|
|50% Industry applications|
|10% Emerging technologies|
This course can count toward your Professional Certificate in Biomanufacturing Science.
Why should you attend?
In this two-day, hands-on course, you will learn the fundamental mechanisms governing both protein precipitation and crystallization, methods for characterizing protein stability and aggregation/crystallization, and strategies to develop appropriate processing conditions. Equipment for aggregation kinetics monitoring and use of that data for protein precipitation and crystallization process development.
Protein precipitation and crystallization are being considered as alternative processes to traditional product purification steps like chromatography and for high concentration formulations in the biomanufacturing arena. Additionally, participants will be introduced to process parameters that affect yield, purity, and efficiency. Process implementation of these methods as semi-continuous or continuous operations will be discussed. Finally, attendees will be introduced to analytical instrumentation that can be used to characterize protein stability, precipitation, and crystallization, including a fluorescence-based thermal shift assay, dynamic and static light scattering, scanning electron microscopy, and real-time on-line monitoring methods.
Attend and you will learn
- To identify opportunities to utilize precipitation or crystallization in downstream processing
- To understand drivers of protein stability, precipitation, and crystallization
- To use multiple analytical techniques to support precipitation and crystallization process development
Who should attend
This course is intended for scientists and engineers working in process development, separations, and formulation sciences. Other groups that may benefit from this course include graduate students and faculty working in areas including bioprocess separations and formulation development.
Attend and you will receive
- 14 hours of instruction
- Notebook containing all course lecture and lab materials
- Morning coffee and tea
- Afternoon beverage break
- Certificate of completion
- John van Zanten, Ph.D.
- Sara Siegel, Ph.D.
- Hunter Brown
All courses are offered on site at BTEC, other than online courses. The Golden LEAF BTEC building is located at 850 Oval Drive on NC State University's Centennial Campus.
If a course is full: Waitlist policy
If a course you want to take is already full, you are welcome to email email@example.com and ask to be placed on a waitlist for that course. The waitlist is used to fill any seats that become available when individuals registered for the course are unable to attend. If one or more seats become available, individuals on the waitlist are contacted in the order in which they were added to the list.
In addition to ensuring popular courses remain full, waitlists provide a means of tracking interest and determining if additional sessions are necessary. BTEC makes every effort to schedule additional course offerings if sufficient people are wait-listed. If a new offering is scheduled, those on the waitlist are notified before registration opens to the public.
Placement on a waitlist does not commit individuals to attending a course. It simply ensures that they are given first opportunity to enroll if a seat becomes available in a full course and that they are among the first to know if an additional course offering is scheduled during the current year.
BTEC is unable to provide information about the number of those wait-listed for any given course or an individual's place on such a list.
BTEC requires payment by credit card at the time of registration. BTEC accepts payment from all major credit cards including American Express, Visa, and MasterCard.
After registration, a payment receipt is automatically emailed. If you do not receive the email, please check your spam folders.
Any additional questions prior to registration should be directed to firstname.lastname@example.org.
A 40% discount is available for NIIMBL members for the following courses:
- Hands-On cGMP Biomanufacturing of Vectors for Gene Therapy
- Hands-on Essentials of Automation for Biomanufacturing
Check out BTEC’s professional development certificate program for an additional way to save money on short course costs. Any additional discount questions prior to registration should be directed to Scott Latus at email@example.com.
Cancellation by registrant
To cancel a registration and be eligible for a refund of course fees, you must notify BTEC by email to firstname.lastname@example.org or fax to 919-513-1697. Fees are refunded according to the following schedule:
- 100% refund – If notification is received at least 15 business days in advance of course start date
- 75% refund – If notification is received 10–14 business days in advance of course start date
- 50% refund – If notification is received 6–9 business days in advance of course start date
- No refund will be issued if notice is received 5 or fewer business days in advance of course start
Refunds will take 60–90 days for processing.
Substitutions may be made up to two business days prior to the course start date. Notify the BTEC office by fax at 919-513-1697 or by email to email@example.com. Please include the name and email contact for the replacement. Please note that BTEC is unable to honor substitutions for individuals taking discounted courses as part of the professional development certificate program.
Cancellation by BTEC
BTEC retains the right to cancel a professional development short course no less than 10 business days in advance of the scheduled course start date. Registrants will be notified by BTEC if a course is cancelled and will receive a full refund of registration fees paid. BTEC is not responsible for airfare penalties or other costs incurred due to cancellation.
Upon successful registration for a course, you will receive an automatically-generated email as well as another email from Melody Woodyard confirming your registration. If you do not receive these emails within two business days of registering for a course, please email firstname.lastname@example.org to confirm your registration.
Once registered, confirmed course participants will receive a series of emails approximately three weeks before the scheduled course with detailed information regarding travel to BTEC, parking information, and a short pre-course questionnaire.