Applied Monitoring and Control for Advanced Biomanufacturing

Delivery methods

Course content

Why should you attend?

To obtain knowledge of advanced manufacturing technologies to monitor and control biomanufacturing operations within a regulatory and industry 4.0 framework. Engage in hands-on experiences that incorporate advanced sensors, data analytics, and control strategies. Learn how to handle, condition, and analyze multivariate data matrices using commercial software packages.

Attend and you will learn

  • What are Advanced Process Controls (APC) and how can we apply APC to the manufacturing of biopharmaceuticals
  • Example of Artificial Intelligence (AI) tools can be used to support biopharmaceutical operations
  • The intention/expectations of the PAT initiative within a scientific and regulatory context
  • How to handle multivariate data as well as to generate Machine Learning descriptive/predictive process models
  • The concept of “soft sensing” and how to design a soft sensor using a machine-learning algorithm
  • Understand the concepts of process condition monitoring and predictive maintenance
  • The basics of modeling spectroscopic data and how to generate real-time bioreactor predictive models—using Raman spectroscopy, as an example
  • The different control strategies used during bio-reactions
  • The differences between some of the most commonly used advanced bioprocess analyzers as well as their capabilities and limitations
  • How to set-up a process analyzer to monitor a bioreactor— using Raman spectroscopy, as an example

Who should attend

Scientists, engineers or consultants working in the biomanufacturing industry with roles in:

  • Automation
  • Process development
  • Manufacturing sciences
  • R&D
  • Manufacturing/operations

Attend and you will receive

  • 21 hours of instruction
  • Notebook containing all course lecture
  • Morning coffee
  • Lunch
  • Afternoon beverage break
  • Certificate of attendance


Saly Romero-Torres, Ph.D.
BTEC Fellow and Senior Manager of Advanced Data Analytics at Biogen

Chris McCready
Lead Data Scientist at Sartorius Stedim Data Analytics AB

Justin Moreto
Senior Scientist at Kaiser Optical Systems




All courses are offered on site at BTEC, other than online courses. The Golden LEAF BTEC building is located at 850 Oval Drive on NC State University's Centennial Campus.


BTEC strongly prefers payment by credit card at the time of registration. BTEC accepts payment from all major credit cards including American Express, Visa, and MasterCard. If you are not paying by credit card at the time of registration, please email to make arrangements immediately after registering and note the following:

  • If you wish to pay by company check or wire transfer, please note that payment is due within 10 days of registration and seats can not be held longer without payment or confirmation of a pending payment.
  • If your company requires an invoice for processing, and the invoice needs to reference a PO number, please include the PO number in your email. Please note that a PO number will not hold a seat.
  • If you wish to pay by wire transfer, please note that BTEC will add a 2% wire transfer fee to the total cost of the course.
  • If no payment arrangements/confirmations have been received within 10 business days of registration, BTEC reserves the right to cancel registration based on enrollment demand.

Any additional questions prior to registration should be directed to

Discounts available

A 20% discount is available to:

A 30% discount is available to faculty/staff working in academic environments.

A 40% discount is available for NIIMBL members for the "Hands-On cGMP Biomanufacturing of Vectors for Gene Therapy" and "Hands-on Essentials of Automation for Biomanufacturing" courses.

Check out BTEC’s professional development certificate program for an additional way to save money on short course costs.

Short course cancellations

Cancellation by registrant

To cancel a registration and be eligible for a refund of course fees, you must notify BTEC by e-mail to or fax to 919-513-1697. Fees are refunded according to the following schedule:

  • 100% refund – If notification is received at least 15 business days in advance of course start date
  • 75% refund – If notification is received 10–14 business days in advance of course start date
  • 50% refund – If notification is received 6–9 business days in advance of course start date
  • No refund will be issued if notice is received 5 or fewer business days in advance of course start

Substitutions may be made up to two business days prior to the course start date. Notify the BTEC office by fax at 919-513-1697 or by e-mail to Please include the name and email contact for the replacement. Please note that BTEC is unable to honor substitutions for individuals taking discounted courses as part of the professional development certificate program.

Cancellation by BTEC

BTEC retains the right to cancel a professional development short course no less than 10 business days in advance of the scheduled course start date. Registrants will be notified by BTEC if a course is cancelled and will receive a full refund of registration fees paid. BTEC is not responsible for airfare penalties or other costs incurred due to cancellation.

Pre-Course Communication

Upon successful registration for a course, you will receive an automatically-generated email as well as another email from Melody Woodyard confirming your registration. If you do not receive these emails within two business days of registering for a course, please email to confirm your registration.

Once registered, confirmed course participants will receive an email approximately two weeks before the scheduled course with detailed information regarding travel to BTEC, parking information, and a short pre-course questionnaire.