Next-Generation Biopharmaceutical Downstream Process (nextBioPharmDSP) Symposium
Wednesday, Jan. 16
9:30 a.m.–4:00 p.m.
Make plans to attend the Next-Generation Biopharmaceutical Downstream Process (nextBioPharmDSP) Symposium at BTEC Wednesday, Jan. 16, 2019. The event, hosted by Millipore Sigma and BTEC, will explore the implementation of a fully integrated manufacturing platform, and attendees will learn about the work that has been done to achieve the nextBiopharmDSP project objectives, including:
- Implementing a fully integrated manufacturing platform based on continuous chromatography
- Single-use disposable techniques for all unit operations of downstream processing sequence for mAbs at pilot or small production scale
- Incorporating advanced analytical tools into your process
Presentation topics will include the following:
- Primary separation: Substitution of the standard process for primary separation with the utilization of flocculants and tangential flow filtration (TFF).
- Continuous capture step: Integration of continuous chromatography in the capture step and development of novel disposable equipment for larger scale. Additionally, non-chromatographic capture step alternatives, such as continuous precipitation.
- Disposable downstream processing: Evaluation of single-use disposable solutions for flow-through polishing steps for efficient removal of impurities and single-pass TFF (SPTFF) as continuous product concentration approach.
- Advanced analytical tools: Different tools for measuring impurities, product content and other parameters in real time or close to real time.
nextBioPharmDSP project partners are Lek Pharmaceuticals d.d., Sandoz GmbH (Austria), Millipore SAS (France), Universität für Bodenkultur Wien (Austria), Karlsruhe Institute of Technology (Germany), National Institute of Chemistry (Slovenia), and National Systems srl (Italy).
The event is presented without charge as an outreach service to current and aspiring industry professionals. Refreshments will be served.
This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 635557.