The University Certificate in Biomanufacturing is designed both for NC State students and for persons from outside the University who wish to gain a recognized competence listed on an NC State transcript without relying on a lengthier program such as a minor.

Total hours required: 12 (All courses must be completed with a grade of C- or better)

A. Prerequisite Courses to Enter the Program

Complete one of the following courses:

• BEC (MB) 320 - Fundamentals of Microbial Cell Culture 
• MB 352 - General Microbiology Lab
• BIT 410 - Manipulation of Recombinant DNA

B. Base Biomanufacturing Sequence (4 credits)

Complete Groups 1 and 2:

1. BEC(MB) 420 – Fundamentals of Microbial Cell Biotransformations, 2 credits or CHE(BEC) 463 - Fermentation of Recombinant Microorganisms, 2 credits

2. BEC 330 - Principles and Applications of Bioseparations, 2 credits

C. Biomanufacturing Specialization (4 credits)

Students must complete a two-course specialization sequence focused on either:

Upstream Operations

BBS 426 - Industrial Microbiology & Biomanufacturing Laboratory, 2 credits and BEC 480 - cGMP Fermentation Operations, 2 credits

or

Downstream Operations

BEC 436 - Introduction to Downstream Process Development, 2 credits and BEC 485 - cGMP Downstream Operations, 2 credits

D. Elective Courses (4 credits)

Complete at least 4 credits of elective courses (if not taken to satisfy a previous section)

• See “Electives for All BTEC Programs”

Electives for All BTEC Programs

• GN 311 - Principles of Genetics, 4 credits
• BAE(BBS) 425 - Industrial Microbiology and Bioprocessing, 3 credits
• BBS 426 - Industrial Microbiology & Biomanufacturing Laboratory, 2 credits
• BCH 451 - Principles of Biochemistry, 4 credits
• BEC 436 - Introduction to Downstream Process Development, 2 credits
• BEC 442 - Insect Cell Protein Expression, 2 credits
• BEC 462 - Bionanotechnology Laboratory, 2 credits
• BEC(CHE) 463 - Fermentation of Recombinant Microorganisms, 2 credits
• BEC 475 - Global Regulatory Affairs for Medical Products, 3 credits
• BEC 480 - cGMP Fermentation Operations, 2 credits
• BEC 485 - cGMP Downstream Operations, 2 credits
• BEC 488 - Cell Culture Engineering, 2 credits
• BEC 497 - Biomanufacturing Research Projects, 1- 2 credits
• BIT 410 - Manipulation of Recombinant DNA, 4 credits
• BIT 466 - Animal Cell Culture technique, 2 credits
• BIT 470 - Advanced Animal Cell Culture: Bioreactor Culture, 2 credits
• BME(BEC) 483 - Tissue Engineering Technologies, 2 credits
• MB 455 - Microbial Biotechnology, 3 credits